Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring

Every year, surgical interventions, traumatic wounds, and burn injuries lead to over 80 million scars. These scars often compromised skin function can result in devastating disfigurement, permanent functional loss, psychosocial problems, growth retardation. Today, a wide variety of nonsurgical scar management options exist, with only few them being substantiated by evidence. The working mechanisms physical anti-scarring modalities remained unclear for many years. Recent evidence underpinned the important role mechanical forces remodeling, especially balance between matrix stiffness cytoskeleton pre-stress. This perspective article aims translate research findings at cellular molecular levels into interventions. Mechanomodulation applied right amplitude, frequency, duration induces ECM remodeling restores ‘tensile’ homeostasis. Depending on characteristics, specific (combinations of) non-invasive treatments are possible. Future studies should be aimed investigating dose-dependent effects define proper guidelines these